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V. Murugan ¹, Brijesh Joshi ¹, K. M. Geetha ¹

Affiliations
1 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bengaluru-560078, Karnataka State, IN

Abstract

2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl)-1,3- thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.

Keywords

2-Imino-5-(4-Substituted Arylidene)-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-1, 3-Thiazol-4-One, CNS Depressant, Antimicrobial Activity.

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V. Murugan ¹, S. Revathi ², K. Sumathi ³, K. M. Geetha ¹, Kalpana Divekar ¹

Affiliations
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN

Abstract

A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.

Keywords

Synthesis, Pyrazoline Derivatives, Anticancer Activity, Dalton’s Lymphoma Ascite (DLA) Cell Line.

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Shelly Thomas ¹, K. M. Geetha ², V. Murugan ²

Affiliations
1 Department of Pharamaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ooty, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore-560078, Karnataka State, IN

Abstract

The reaction of 2-Hydrazino-N-[4-(5-methyl benzoxzol-2-yl)-phenyl]-acetamide (III) with various aldehydes to get 2-(N¹-Substituted hydrazino)-N-[4-(5-methyl-benzoxazol-2-yl)-phenyl]-acetamide. The structures of the synthesized compounds were settled on the basis of spectral data. The newly synthesized compounds were tested for their possible antimicrobial and anti-inflammatory activities. After 3 hr, all the tested benzoxazole compounds showed statically significant decrease in the paw volume and all the compounds were tested for their antimicrobial activities none of the compounds showed activity at the concentration of 1000 μg/well.

Keywords

Benzoxazole Derivatives, Anti-Inflammatory, Antimicrobial Activity.

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